Colombian authorities have arrested 52 people linked to international drug trafficking in a major operation supported by the United States, France and Spain, the defence ministry said Wednesday.

Of those arrested, 34 were under "current extradition orders", Defence Minister Ivan Velasquez said.

After two years of investigation, Colombian authorities uncovered the suspects during an operation which lasted two months, and resulted in the seizure of "four tonnes of cocaine worth US$134 million," he added.

In a statement, the ministry said the suspects "were linked to international Mexican organisations such as the Sinaloa Cartel, Jalisco New Generation, Los Zetas as well as European organizations such as Clan Devesa."

Those arrested included Mexicans Carlos Omar Felix and Silvano Francisco Mariano from the Sinaloa cartel accused of trafficking fentanyl to the United States.

A Slovak citizen, Michal Pis, who is accused of marketing methamphetamines in his country, the Czech Republic and Germany, was also among those detained, along with a British man who coordinated shipping drugs to Belgium and a Chilean money launderer.